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Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
Jun Zhao, Xiaofei Wen, Tian Li, Tingting Li +7
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Abstract
T cells and significantly prolongs survival in a murine orthotopic PDAC model with a long-term memory immune response. Our results suggest that IRE is a promising approach to potentiate the efficacy of immune checkpoint blockade in PDAC.
Keywords
StromaCancer researchBlockadeIrreversible electroporationImmune checkpointImmunotherapyImmune systemPancreatic cancerMedicineCD8Immunogenic cell deathImmunosuppressionElectroporationCancerImmunologyBiologyReceptorInternal medicineImmunohistochemistry
Identifiers
- Journal
- Nature Communications
- Year
- 2019