Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Joan Estelrich, Elvira Escribano, Josep Queralt, Maria Antònia Busquets
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Abstract
In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.
Keywords
Identifiers
- Journal
- International Journal of Molecular Sciences
- Year
- 2015