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Abstract

Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review.

Keywords

Surface plasmon resonanceNanotechnologyBiosensorPlasmonComputer scienceSurface plasmonResonance (particle physics)Materials scienceOptoelectronicsPhysicsNanoparticle

Identifiers

DOI
10.3390/s150510481
Journal
Sensors
Year
2015