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Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9
Hyunduk Jang, Sang Eun Lee, Jimin Yang, Hyun-Chae Lee +17
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Abstract
We identified CAP1 as a new binding partner of PCSK9 and a key mediator of caveolae-dependent endocytosis and lysosomal degradation of LDLR.
Keywords
Proprotein convertaseKexinPCSK9LDL receptorInternalizationSubtilisin
Identifiers
- PubMed
- 31419281
- Journal
- European Heart Journal
- Year
- 2019