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Biocatalytic Reduction Reactions from a Chemist's Perspective
Frank Hollmann, Diederik J. Opperman, Caroline E. Paul
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Abstract
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive aminations.
Keywords
ChemoselectivityChemistryCombinatorial chemistryOrganic chemistryBiocatalysisEnoneCatalysisReaction mechanism
Identifiers
- Journal
- Angewandte Chemie International Edition
- Year
- 2020