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MES research in membrane, bacteria. Glutamate amidation, a secondary modification of the peptidoglycan, was first i...

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Abstract

Glutamate amidation, a secondary modification of the peptidoglycan, was first identified in Staphylococcus aureus . It is catalyzed by the protein products of the murT and gatD genes, which are conserved and colocalized in the genomes of most sequenced Gram-positive bacterial species. The MurT-GatD complex is required for cell viability, full resistance to β-lactam antibiotics, and resistance to human lysozyme and is recognized as an attractive target for new antimicrobials.

Keywords

PeptidoglycanLysozymeStaphylococcus aureusBacterial cell structureCell wallMicrobiology

Identifiers

DOI
10.1128/aac.00957-19
Journal
Antimicrobial Agents and Chemotherapy
Year
2019