Global burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
AI summary
75% confidenceThis study provides updated global, regional, and national estimates of lower respiratory infection (LRI) incidence, mortality, and DALYs from 1990 to 2023, attributing cases to 26 pathogens including 11 newly modeled ones. It serves as an expansion of the GBD 2021 data to better assess progress toward the 2025 Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea targets.
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Abstract
Lower respiratory infections (LRIs) remain the world's leading infectious cause of death. This analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides global, regional, and national estimates of LRI incidence, mortality, and disability-adjusted life-years (DALYs), with attribution to 26 pathogens, including 11 newly modelled pathogens, across 204 countries and territories from 1990 to 2023. With new data and revised modelling techniques, these estimates serve as an update and expansion to GBD 2021. Through these estimates, we also aimed to assess progress towards the 2025 Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea (GAPPD) target for pneumonia mortality in children younger than 5 years.
Key findings
- LRIs remain the leading infectious cause of death globally, with significant variations in burden across different regions and age groups.
- The inclusion of 11 newly modeled pathogens offers a more comprehensive understanding of LRI etiologies compared to previous studies.
- Progress toward the 2025 GAPPD target for pneumonia mortality in children under five years requires continued focus on high-burden regions.