Microfluidics for Biofilm Studies
Lu Yuan, Hervé Straub, Liubov Shishaeva, Qun Ren
AI summary
70% confidenceBiofilms are multicellular communities of bacteria that exhibit unique properties and can be studied using microfluidics to control their hydrodynamic and physicochemical microenvironments. Recent progress in microfluidics-based biofilm research has advanced our understanding of bacterial adhesion, biofilm development, and antifouling/antimicrobial properties. This research has also led to the development of advanced in vitro infection models and new methods for characterizing biofilms.
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Abstract
Biofilms are multicellular communities held together by a self-produced extracellular matrix and exhibit a set of properties that distinguish them from free-living bacteria. Biofilms are exposed to a variety of mechanical and chemical cues resulting from fluid motion and mass transport. Microfluidics provides the precise control of hydrodynamic and physicochemical microenvironments to study biofilms in general. In this review, we summarize the recent progress made in microfluidics-based biofilm research, including understanding the mechanism of bacterial adhesion and biofilm development, assessment of antifouling and antimicrobial properties, development of advanced in vitro infection models, and advancement in methods to characterize biofilms. Finally, we provide a perspective on the future direction of microfluidics-assisted biofilm research.
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Identifiers
- Journal
- Annual Review of Analytical Chemistry
- Year
- 2023