A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients.
Marith I. Francke, Sebastiaan D. T. Sassen, Núria Lloberas, Helena Colom +7
AI summary
75% confidenceThis study developed a population pharmacokinetic model to predict individualized tacrolimus dose requirements in kidney transplant recipients, addressing the drug's narrow therapeutic range and variability. The model aimed to guide starting and follow-up doses for both living and deceased donor kidney transplants. The goal was to improve treatment outcomes by optimizing tacrolimus dosing.
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Abstract
Tacrolimus treatment is complicated by its narrow therapeutic range and large inter- and intra-patient variability. This study aimed to develop a population pharmacokinetic model and dosing algorithm to predict an individual's dose requirement following living and deceased donor kidney transplantation.
Key findings
- A population pharmacokinetic model was successfully developed to predict tacrolimus exposure
- The model accounted for inter- and intra-patient variability in tacrolimus pharmacokinetics
- A dosing algorithm was created to guide individualized tacrolimus dosing in kidney transplant recipients
Keywords
Identifiers
- PubMed
- 40588615
- Journal
- Clinical pharmacokinetics
- Year
- 2025