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80% confidenceMES research in bacteria. This chapter focuses on bacterial pathogenesis. Most of the bacteria that colonize our bodies do ...
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Abstract
This chapter focuses on bacterial pathogenesis. Most of the bacteria that colonize our bodies do so without causing us any harm. However, some bacteria are inherently more damaging than others. Their degree of pathogenicity is described in the term ‘virulence’, which can be quantified by establishing experimental metrics such as median lethal dose and median time to death. Virulence and pathogenicity are dependent upon the composition of the bacterial genome; pathogen genomes encode many virulence factors which operate in a concerted fashion to express pathogenicity. The chapter then describes the characteristics of pathogenic bacteria that allow them to adhere to epithelial surfaces (adhesins), evade the immune system (evasins and impedins), invade tissues (invasins), and damage underlying tissues (toxins). It looks at toxinogenesis and considers pan-genomes, mobile genetic elements, and the acquisition virulence factors.
Keywords
Identifiers
- Journal
- Medical Microbiology
- Year
- 2019