Nanoparticle-Mediated Biofilm Eradication: Overcoming Multidrug Resistance in Clinical Pathogens
Gadakh P. V.
AI summary
75% confidenceNanoparticle-mediated biofilm eradication is a promising approach to overcome multidrug resistance in clinical pathogens, effectively combating biofilms by improving drug delivery and exerting antimicrobial activity. Recent advances in nanoparticle-based strategies show disruption of biofilm structure and targeted antimicrobial delivery. These approaches outperform traditional antibiotics in reducing biofilms.
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Abstract
Biofilm-associated infections remain a major challenge in healthcare due to biofilms’ ability to protect bacteria from antibiotics and host immune responses, contributing significantly to the rise of antimicrobial resistance (AMR). Nanoparticle (NP)-based strategies effectively combat biofilms by improving drug delivery, penetrating biofilm matrices, and exerting antimicrobial activity. Recent advances in metallic, polymeric, and lipid nanoparticles targeting biofilm-forming bacteria show disruption of biofilm structure, reactive oxygen species (ROS) generation, quorum-sensing inhibition, and targeted antimicrobial delivery. These approaches outperform antibiotics in reducing biofilms; optimizing design, safety, and clinical translation is key for MDR treatment.
Key findings
- Disruption of biofilm structure
- Reactive oxygen species (ROS) generation
- Quorum-sensing inhibition
Keywords
Identifiers
- Journal
- World Journal of Biology Pharmacy and Health Sciences
- Year
- 2026