Biomimetic Metal-organic Framework Composites Mediated Cascade Catalysis for Synergistic Bacteria Killing.

Abstract

Encapsulating nanopartiles/biomolecules into metal-organic freamworks (MOFs) has proven highly effective in creating new functions during their applications. However, it is highly desirable yet remains challenging to achieve the synergy of specific functions between MOF host and guest species. Herein, inspired by natural multienzyme system, a novel MOF composite biomimetic structure based on co-encapsulation of glucose oxidase (GOx) and L-arginine (L-Arg) into Cu-MOFs (CuBDC) with Fenton-like catalytic activity is designed for achieving synergistic antibacterial effect. Once activated by GOx-catalyzed glucose oxidation, a large amount of oxygen radicals, toxic ONOO- and NO are rapidly produced over this well-designed L-Arg/GOx@CuBDC through a double-cascade reaction. Thanking to the synergy of highly reactive species, outstanding antibacterial effects (bacterial inactivation ≥97%) are observed at very low doses (38 μg mL⁻¹ for E. coli and 3.8 μg mL⁻¹ for S. aureus). In addition, the in vivo experiment in mice demonstrated that the as-prepared L-Arg/GOx@CuBDC has good biocompatibility, indicating its good potential in practical applications. Such biomimetic multienzyme system proposes a new design idea for highly efficient antibiosis as well as even therapy of tumors.

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Identifiers

DOI

10.1021/acsami.0c12159

Journal

ACS Applied Materials & Interfaces

Year

2020