Electrochemical analysis of drugs using boron-doped diamond thin film electrode in flow injection system

Abstract

In this research, electrochemical analysis of drugs using a boron-doped diamond thin film electrode has been studied. Drugs, including acetaminophen, D-penicillamine and barbituric acid were investigated. The electrochemistry of drugs was studied by cyclic voltammetry. Comparison experiments were carried out using a polished glassy carbon (GC) electrode. At the diamond electrode, well-resolved cyclic voltammograms were obtained with current signal to background ratios higher than that obtained from the glassy carbon electrode. Detection limits of 10, 25 and 50 micrometre for acetaminophen, D-penicillamine and barbituric acid, respectively were obtained at the diamond electrode. Flow injection with amperometric detection using the diamond electrode was also studied. A significant low detection limit at 10 nM with signal to noise ratios higher than 3 and a linear range over 2-3 orders of magnitude were obtained. The purposed method was further applied to real drug samples in pharmaceutical preparations. These were paracetamol syrup and penicillamine capsule. The results obtained were satisfactory.

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Identifiers

DOI

10.58837/chula.the.2001.985

Journal

Unknown journal

Year

2001