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Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes
E. Cebrián-Sastre, A. Chiner-Oms, R. Torres-Pérez, I. Comas +3
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90% confidenceMES research in bacteria. Rifampicin is the most important first-line antibiotic against mycobacterial infections, inc...
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Abstract
Rifampicin is the most important first-line antibiotic against mycobacterial infections, including tuberculosis, one of the top causes of death worldwide. Acquisition of rifampicin resistance constitutes a major global public health problem that makes the control of the disease challenging.
Keywords
RifampicinrpoBMycobacterium tuberculosisDrug resistanceAntibiotic resistanceMutation rate
Identifiers
- Journal
- Microbiology Spectrum
- Year
- 2023