Voltammetric Determination of Clozapine in Pharmaceutical Formulations and Biological Fluids Using an In Situ Surfactant‐Modified Carbon Ionic Liquid Electrode
M. Arvand, M. Ghasempour Shiraz
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100% confidenceMES research in electrode, performance. Abstract A carbon ionic liquid electrode modified in situ with sodiu...
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Abstract
Abstract A carbon ionic liquid electrode modified in situ with sodium dodecylsulfate (SDS) was developed for the determination of clozapine (CLZ). These studies revealed that the oxidation of CLZ is facilitated at an in situ surfactant‐modified carbon ionic liquid electrode (ISS‐CILE). After optimization of analytical conditions, the peak currents for CLZ were found to vary linearly with its concentrations in the range of 1×10 −9 –1×10 −7 mol L −1 with a slope of 2.18 µA/µmol L −1 . The LOD and LOQ of the electrode were 2.08×10 −10 mol L −1 and 6.95×10 −10 mol L −1 , respectively. The proposed method was employed for the determination of CLZ in pharmaceutical formulations, blood serum and plasma samples without any pretreatment steps.
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- Journal
- Electroanalysis
- Year
- 2012