Biocompatible Surface Modification with DNA and Proteins for Carbon Electrode-Based Biosensing

Abstract

Electrochemical biosensors, which combine biorecognition elements with electrochemical readout to enable sensitive and specific sensing using inexpensive, simple equipment, are a major area of research for the development of “point-of-care” (POC) diagnostics that can be utilized in low-resource settings. Commercially available screen-printed carbon electrodes (SPCEs) are often used for electrochemical biosensors due to its low cost and fabrication from abundant resources. Forming a high quality, stable, and homogenous layer of biomolecules on the carbon surface is crucial for efficient sensing; however, the chemistries used to modify carbon electrodes with biomolecules are either insufficiently specific, susceptible to stripping, or unapproachable due to over-engineering. In this talk, I describe a new, simple chemical strategy to functionalize carbon electrodes with biomolecules for the electrochemical detection of nucleic acids, enzymes, and whole cells.

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Identifiers

DOI

10.1149/ma2023-01412349mtgabs

Journal

ECS Meeting Abstracts

Year

2023