A Simple Nickel Metal-Organic Framework-Catalyzed Borylation of Aryl Chlorides and Bromides.
Aishwarya Prakash, Suma Basappa, Bhavya Jeebula, D. H. Nagaraju +2
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70% confidenceA nickel-benzene tricarboxylic acid metal-organic framework (Ni-BTC MOF) catalyst system is reported for efficient borylation of aryl halides with high yields and selectivity.
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Abstract
We report a recyclable and efficient catalyst system based on a nickel-benzene tricarboxylic acid metal-organic framework (Ni-BTC MOF) for the borylation of aryl halides, including aryl chlorides, with bis(pinacolato)diboron, affording aryl boronate esters in high yields (up to >99% yield) with high selectivity. This protocol demonstrates broad functional group tolerance. Catalyst can be recyclable up to four times, and gram-scale reactions further highlights the usefulness of this method. In situ EPR experiments confirmed the formation of catalytically active Ni(I) species.
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Identifiers
- Journal
- Organic Letters
- Year
- 2024