Attending ISMET 2025 in Leipzig?
Learn how you can contribute to MESSAI →

Electrochemical Biosensor Design

Signal-to-noise optimizationDetection limit theoryBiofilm electrode designMediator chemistryInterference suppression

Biosensor Design Optimization

Signal-to-noise analysis for electrochemical biosensors

0.25 cm²
15 μm
2.5 mM
100 mg/L
25°C
7.0
0.10 M
10 mg/L

Signal Current

2.20 μA

Electrochemical response

Signal-to-Noise Ratio

1.4

Poor

Detection Limit

216.00 mg/L

3σ criterion

Response Time

5 s

Diffusion limited

Additional Metrics

Sensitivity:0.022 μA/(mg/L)
Selectivity:60.7%
Total Noise:1.581 μA

Detection Curve Preview

1 mg/L:Below LOD
6 mg/L:Below LOD
11 mg/L:Below LOD
16 mg/L:Below LOD
21 mg/L:Below LOD

Optimization Tips

Increase electrode area or reduce biofilm thickness to improve SNR. Lower mediator concentration may reduce detection limit. Reduce interferent concentration or use selective membranes.